However, with prolonged treatment, CRC becomes resistant to BMS-1166, leading to the phosphorylation of tyrosine residues in the cytoplasmic region of immune receptor tyrosine conversion motif (ITSM) domain induced by PD-L1 binding to PD-1 and the recruitment of protein tyrosine phosphatase 2 (SHP-2) in the Src homologous domain. This evidence concerns the gene CD274 and colorectal carcinoma.