Moreover, other studies demonstrate that neutrophil CD64 expression shows a relatively weak association with sepsis mortality (AUC < 0.8) (Livaditi et al., 2006; Dimoula et al., 2014), while the AUCs of CYSTM1, MMP8, and CD177, which are strongly associated with a variety of immune cells, were 0.988, 0.973, and 0.986, respectively, in predicting pediatric sepsis (Zhang et al., 2023). This evidence concerns the gene CYSTM1 and Sepsis.