Among the included variables that were identified based on univariate analysis, HGB (OR = 0.78, p = 0.031), TB (OR = 1.447, p = 0.003), γ-GT (OR = 2.531, p = 0.009), Cr (OR = 1.392, p = 0.034), and FDP (OR = 2.647, p = 0.002) demonstrated their potential in serving as independent risk factors for distinguishing severe respiratory infection, although the expression of mt-CO1, mt-ND1, and mt-ATP6 had been recorded to be extremely reduced in the S group. Here, MT-ND1 is linked to respiratory tract infectious disorder.