PRF1 and colitis: The mRNA levels of Tmem173, and inflammatory genes associated with colitis progression were all significantly downregulated, while the expression of genes involved in cytotoxic lymphocyte (CTL)-mediated tumor immunity, including Gzmb, Perforin, and Cd8 were all significantly elevated in Tmem173iΔmye AOM+DSS-P group, when compared with Tmem173fl/fl mice (Figure 7F-G).