Recent research has indicated that faulty maturation of CMs may play a role in the development of cardiomyopathy, as the absence of certain proteins related to DCM, including PGC, MYH6, TPM1, RYR2, and SIRT1, can hinder the maturation processes of CMs, such as sarcomere expansion, electrophysiology, and oxidative metabolism 5, 7, 8, 17. Here, SIRT1 is linked to familial dilated cardiomyopathy.