LYZ and inflammatory bowel disease: To investigate AhR functions in modulating the role of macrophages in IBD pathogenesis, we generated mice with myeloid cell-specific knock-out of AhR (AhRfl/fl;LysM-Cre+, hereafter AhR△Mye mice) by crossing lysozyme-cre mice with AhRfl/fl mice (Figure S3A-B); co-housed littermates AhRfl/fl mice were used as controls.