To determine which transcription factors might mediate exercise-alleviated atherosclerosis, we integrated the CUT &Tag and ATAC-seq data and examined the distribution of MeCP2 K271 lactylation and H3K36me3 modifications in relation to regions of open chromatin identified by ATAC-seq in exercised and sedentary ApoE-/- mice. Here, APOE is linked to atherosclerosis.