Additionally, to eliminate the potential impact of external factors on LRRC8A-/- mouse lymphopenia, the authors generated a chimeric LRRC8A-/-→Rag2-/- mouse model by transplanting LRRC8A-/- bone marrow cells into Rag2-/- mice, that do not produce T and B lymphocytes. The gene discussed is LRRC8A; the disease is lymphopenia.