OTUB1 and bladder transitional cell carcinoma: Further analysis showed that most members' expression of the OTU deubiquitinase family was dysregulated in BLCA tissue, OTUB1 was the most prominent among all OTU deubiquitinase members because of its significantly elevated levels in BLCA tissue compared with lower expression in normal bladder tissue (Fig. 1B, C, Fig. S1).