In PF, lncRNA MEG3 can inhibit NiO NPs-induced lung fibrosis by regulating autophagy in alveolar epithelial cells, which could be a potential therapeutic strategy for PF 146; circHECTD1 overexpression or HECTD1 knockdown reverses SiO2-induced autophagy in human primary lung fibroblasts and restores SiO2-induced fibroblasts through downstream autophagy activation, proliferation, and migration 147; CDKN2B-AS1 promotes lung fibroblast autophagy to alleviate the development of IPF through the miR-199a-5p/SESN2 axis 148. Here, HECTD1 is linked to pulmonary fibrosis.