In renal fibrosis, lncRNA ENST00000453774.1 promotes reactive oxygen species defense and reduces the production of ECM-associated proteins involved in renal fibrosis by activating survival autophagy in proximal tubular epithelial cells of human renal tubules 155, and lncRNA SOX2OT promotes autophagy in tethered cells and attenuates fibrosis due to diabetic nephropathy 156; knockdown of lncRNA-TUG in renal tubular epithelial cells increased miR-223-3p expression and inhibited Klotho function aggravated renal tubular epithelial cell senescence 157. This evidence concerns the gene SOX2-OT and renal fibrosis.