Serine/threonine protein kinase 6 (AuRKA) interacts with heat shock protein 90 (HSP90), whereas HSP90 inhibitors promote ubiquitin-dependent degradation of AuRKA, and a reduction in AuRKA expression induces the differentiation of immature macrophages and reduces the mutational burden of primary myelofibrosis 88. Here, AURKA is linked to myelofibrosis.