LncRNA GAS5 binding to miR-28a-5p inhibited the binding of miR-28a-5p to the 3'-UTR of the E3 ligase MARCH7, resulting in the up-regulation of MARCH7 expression, which interacts with NOD-like receptor protein 3 (NLRP3) proteins, leading to the degradation of the NLRP3 proteasome, which inhibited the inflammation and the deposition of heat proteins, and attenuated the development of NAFLD 181. Here, GAS5 is linked to metabolic dysfunction-associated steatotic liver disease.