In Aristolochic acid-induced renal fibrosis due to acute kidney injury, stable overexpression of miR-192 represses the expression of E3 ubiquitin ligase, murine double-minute 2 (a negative regulator of p53), which arrests the cell cycle in the G(2)/M phase, and this growth arrest promotes proximal renal tubular epithelial cell injury followed by fibrosis 172. The gene discussed is PRKN; the disease is renal fibrosis.