In myocardial fibrosis, the dysregulated expression of lncRNAs TDRG1, LINC01013, HOTAIR, miR-9, and miR-221/222 regulates the activation of ERK/JNK signaling pathway, the proliferation, migration, differentiation, and autophagy of cardiac fibroblasts as well as myocardial tissue inflammatory response which in turn promotes the progression of myocardial fibrosis 167, 168. This evidence concerns the gene MAPK8 and Myocardial fibrosis.