In renal fibrosis due to diabetic nephropathy, miR-27b-3p and miR-1228-3p bind to the ubiquitin-binding E2 enzyme variant (UBE2v1) 3'-UTR and inhibit UBE2v1-mediated lysine 63-linked ubiquitin chain formation 169. The gene discussed is UBE2V1; the disease is renal fibrosis.