The ubiquitin-specific protein USP7 interacts with and stabilizes the expression of human leukocyte antigen-F-adjacent transcript 10 (FAT-10), which mediates the up-regulation of CHK1, thereby promoting CHK1-mediated G2/M arrest in renal tubular mesenchymal-epithelial cells and contributing to renal fibrosis 36. This evidence concerns the gene CHEK1 and renal fibrosis.