In liver fibrosis, lncRNA NEAT1 enhances IGFBPrP1-induced autophagy in HSC via the miR-29b/Atg9a axis, thereby promoting the development of liver fibrosis 151; in alcoholic liver fibrosis, lncRNA XIST enhances alcohol-induced HSC autophagy via the miR-29b/HMGB1 axis 152; lncRNA PVT1 induces HSC autophagy under hypoxic conditions via miR-152/ATG14 153; in non-alcoholic cirrhosis, lncRNA MIR22HG inhibits autophagy to increase fibrosis via miRNA-9-3p/IGF1 axis 154. The gene discussed is IGF1; the disease is Hepatic fibrosis.