For instance, Shao et al. established the 10 FRGs signature (TFAP2C, SLC39A8, NOS2, HAMP, GDF15, FDFT1, CDKN2A, ALOX12, AKR1C1, and ATP6V1G2) that may accurately predict the prognosis and survival time of CRC patients 95. This evidence concerns the gene CDKN2A and colorectal carcinoma.