We stimulated mouse HSCs JS-1 with FT@XBP1 nanomaterials in vitro, however, FT@XBP1 could not further activate HSCs stimulated with TGF-β1 as demonstrated using Western blot analysis (Fig. S6A), whereas oil red O staining demonstrated that FT@XBP1 slightly decreased lipid accumulation in PA-stimulated AML-12 cells (Fig. S6B). Here, XBP1 is linked to acute myeloid leukemia.