In the present study, the prediction of human gene-phenotype associations (Fig. 2A) revealed that TEM1 gene was linked to aortic dissection and aneurysm, and the risk is slightly higher in aortic dissection (Z-score: 5.251766) than in aortic aneurysm (Z-score: 4.262546). This evidence concerns the gene CD248 and aneurysm.