Since leflunomide significantly decreased plasma lipid and liver lipid accumulation in WD-fed ApoE-/- mice and FFA-stimulated AML12 cells (Figure 1-5), we thus investigated whether leflunomide and teriflunomide ameliorates endothelial dysfunction and protects vascular function in vitro and in vivo. The gene discussed is APOE; the disease is endothelial dysfunction.