In contrast, H. pyloriWT infection partly disrupted the negative impact of CYP11A1 on CYP19A1: CYP11A1 knockdown could still upregulate CYP19A1; CYP11A1 by PCR overexpression could not downregulate CYP19A1(Figure 4B and Figure S4A) and WB (Figure 4D and Figure S4C). The gene discussed is CYP11A1; the disease is infection.