Enrichment analysis of the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways revealed that CaSR-overexpressing LUAD showed significant changes in cisplatin drug resistance-related pathways compared to the negative control group (Fig. 2F), including BRCA1(Fig. S4C), which plays an important role in homology-directed repair and therapy resistance 35, and BRCA1 is also an important indicator for predicting the efficacy of chemotherapy in NSCLC 36. The gene discussed is CASR; the disease is non-small cell lung carcinoma.