In three models of renal fibrosis (unilateral ureteral obstruction, folic acid nephropathy, and adenine-induced nephrotoxicity), the extent of renal fibrosis was reduced in CPT1A knockin (CPT1A-KI) mice, and a protective effect against fibrosis was seen following inducing CPT1A overexpression 39. The gene discussed is CPT1A; the disease is renal fibrosis.