To date, there have been no more than 10 cases of FPLD6 reported worldwide, including three families from different countries and three unrelated patients with LIPE gene mutations causing multiple symmetric lipomatosis and/or FPLD (Albert et al., 2014; Farhan et al., 2014; Zolotov et al., 2017; Sollier et al., 2021). The gene discussed is LIPE; the disease is LIPE-related familial partial lipodystrophy.