Research indicates that inflammatory mediators and cells associated with AR, such as leukotrienes, immunoglobulin E (IgE), and mast cells, participate in the process of atherosclerosis, which correlates with the occurrence of ED (Radmark, 2003; Schwartz and Kloner, 2011; Theoharides et al., 2011; Zhang et al., 2020). Here, IGHE is linked to atherosclerosis.