CD4 and infection: EVs induced cytokine production, particularly IL‐10, in chronically infected mice. High IL‐10 frequency was observed in CD4+ and CD8+ T‐cells, while B‐cells showed a mixed cytokine profile with TNF‐α and IL‐10. Dendritic cells produced TNF‐α upon EV stimulation. Surface polymorphisms in the vesicles may play a crucial role in immunopathologic events during both early infection and the chronic phase.