AGER and nervous system disorder: Moreover, despite Higashida and colleagues’ (2017) assertion that RAGE is expressed only by vascular ECs and choroid plexus epithelium in the brain, others have detected RAGE in a subset of neurons in the cerebral cortex (Brett and others 1993), with further studies showing RAGE involvement in embryonic and adult neuronal differentiation, neurite outgrowth, and nerve regeneration (Rong and others 2004; Wang and others 2008), as well as pathogenesis of neurologic disorders (Juranek and others 2022).