NKX2-1 and neoplasm: CXCR2 is a pivotal chemokine receptor with tumor‐promoting effects that facilitate the recruitment of leukocytes to inflamed tissues, resulting in tumor growth.[40] In LUAD, CXCR2 is associated with tumor invasion, angiogenesis, and metastasis.[15, 54] Additionally, the CXCLs/CXCR2 axis also plays a crucial role in promoting drug resistance in LUAD.[15] In this context, we demonstrated that the downregulation of NKX2‐1 leads to the upregulation of CXCL1, CXCL2, CXCL3, and CXCL5, which are all ligands of CXCR2.