NKX2-1 and neoplasm: The tumor microenvironment (TME) can affect clinical outcomes due to the ability of innate or adaptive immune cells to exert either tumor‐promoting or tumor‐suppressing effects.[24] The most abundant immune cells that infiltrate tumors are neutrophils and macrophages, which may exert pro‐tumorigenic effects by driving angiogenesis, extracellular matrix remodeling, metastasis, and immunosuppression.[25] Therefore, we aimed to elucidate the impact of NKX2‐1 on the complex interactions between malignant and immune cells within the TME.