NKX2-1 and neoplasm: For instance, previous reports have demonstrated that tumor‐promoting or tumor‐suppressing functions of neutrophils are determined by the functional characteristics exhibited through specific markers[34] related to neutrophil activation and cytokine status.[35] To characterize the neutrophil phenotypes, we applied hierarchical clustering to identify the distinct gene expression patterns in HL‐60 cells cultured with the medium conditioned by NKX2‐1 knockdown cells.