CXCR2 is a pivotal chemokine receptor with tumor‐promoting effects that facilitate the recruitment of leukocytes to inflamed tissues, resulting in tumor growth.[40] In LUAD, CXCR2 is associated with tumor invasion, angiogenesis, and metastasis.[15, 54] Additionally, the CXCLs/CXCR2 axis also plays a crucial role in promoting drug resistance in LUAD.[15] In this context, we demonstrated that the downregulation of NKX2‐1 leads to the upregulation of CXCL1, CXCL2, CXCL3, and CXCL5, which are all ligands of CXCR2. Here, CXCL1 is linked to neoplasm.