Notably, among the CXC chemokines, CXCL1, CXCL2, and CXCL5 were reported to be involved in the paracrine network that mediates tumor progression and metastasis.[45] To further evaluate the molecular events triggered by the tumor‐promoting neutrophils attracted by NKX2‐1‐low LUAD tumors, we analyzed both scRNA‐seq samples (NKX2‐1‐low tumors in comparison with the control) (Figure 3B) and RNA‐seq data from HL‐60 cells co‐cultured with shNKX2‐1/H1975‐conditioned medium compared to HL‐60 co‐cultured with shCtrl/H1975‐conditioned medium. This evidence concerns the gene CXCL2 and neoplasm.