However, Chen et al. noted that RSV pretreatment increased the viability of ADSCs under high glucose stress through the expression of Sirt1 and IGF1R, and the secretion of IGF1 in ADSCs pretreated with RSV also increased, therefore, RSV may be used to treat liver dysfunction in DM patients with liver dysfunction [87]. The gene discussed is SIRT1; the disease is Decreased liver function.