A more specific interaction occurs in renal cell carcinoma with the NONO-TFE3 translocation, where the NONO fragment may maintain the stability of the fusion protein by phase separation to inhibit its degradation, and another TF, NRF1, may form a positive feedback loop with NONO-TFE3 to promote the transcriptional activity of the latter[82]. Here, TFE3 is linked to renal cell carcinoma.