Several in vivo experimental studies have also revealed that TRQI can reduce the expression of IL-8, TNF-α and mucin 5AC (MUC5A) in alveolar lavage fluid in CS-and LPS-induced rats with COPD, thereby improving the inflammatory response of airway mucosa and inhibiting airway mucus hypersecretion in rats [92]. The gene discussed is TNF; the disease is chronic obstructive pulmonary disease.