KLK3 and cancer: Alternative cut-offs for men with a PI-RADS 3 lesion, either a PSA density < 0.15 ng/ml2, a prostate volume ≥ 50 cc or a Stockholm 3 score < 15%, could be used for identifying men with a low risk of clinically significant cancer via combined biopsy (10.3%, 7.2%, and 6.8%, respectively).