Among FMF patients with comorbid disease, 43 patients (23.4%) anti-tumour necrosis factor (TNF) therapy, 36 patients (19.5%) methotrexate, 3 patients (1.6%) azathioprine, 2 patients (1.0%) mycophenolate mofetil, and 2 patients (1.0%) anti-interleukin 6 (IL-6) treatment. This evidence concerns the gene TNF and familial Mediterranean fever.