To further examine the physiological importance of SKIV2L restriction of the OAS-RNase L pathway during viral infection, we challenged WT, SKIV2LKO, RNASELKO, RNASELKOSKIV2LKO cells with Sindbis virus (SINV) that is known to activate OAS-RNase L innate immune pathway (Li et al, 2016). The gene discussed is RNASEL; the disease is viral infectious disease.