In HM tumours, the antigen-presenting genes HLA-B (26%), HLA-A (25%) and TAP2 (24%) had the highest LOH frequency, whereas TRPS1 (26%), ACVR1B (22%), CYP7B1 (22%), MBD6 (22%) and ERBB3 (22%) had the highest frequency of gains (Extended Data Fig. 2a and Supplementary Table 8). This evidence concerns the gene ERBB3 and neoplasm.