PIK3CA and neoplasm: Finally, CRPS5 tumours were often from the right colon (46%), displayed WNT signalling repression (Supplementary Table 26) and had the highest prevalence of KRAS, PIK3CA and FBXW7 mutations, but fewer TP53 mutations and CNVs compared with CRPS2–CRPS4 (Fig. 4b and Extended Data Fig. 6a,b).