Notably, HM tumours with the DNA MMR SBS44 signature were primarily right colon (85% versus 70%, P = 0.0064), BRAF V600E mutated (70% versus 45%, P = 0.0015), less frequently stage IV (4% versus 15%, P = 0.0386) and had longer OS (multivariable hazard ratio (HR) = 0.558, 95% confidence interval (CI) = 0.319–0.974; Extended Data Fig. 3d). Here, BRAF is linked to neoplasm.