Of the fusions, 15 were known CRC drivers, including NTRK, BRAF and ERBB2 fusions, the PTPRK–RSPO3 fusion shown to promote differentiation and loss of stemness39,40, and the uncharacterized FBXO25–SEPTIN14 fusion (Supplementary Fig. 6c,d). The gene discussed is BRAF; the disease is colorectal carcinoma.