For the KRAS, APC and AMER1 group, the nHM tumours had co-occurring PIK3CA (FDR-adjusted P = 1.98 × 10−5) and TCF7L2 (FDR-adjusted P = 4.57 × 10−4) and mutually exclusive TP53 (FDR-adjusted P = 1.06 × 10−7) and NRAS (FDR-adjusted P = 1.76 × 10−6) mutations. This evidence concerns the gene PIK3CA and neoplasm.