Among them, (1) TP53 and 17p loss are known early mutations that are frequently found in multiple cancers; (2) APC, KRAS, BRAF and TP53 mutations drive CRC development; and (3) ZFP36L2, TCF7L2, BCL9L and SOX9 are previously unknown early events in cancer26. This evidence concerns the gene BRAF and colorectal carcinoma.