The signatures SBS10a and SBS10b, associated with MSS POLE mutated tumours, co-occurred with SBS2829 (r = 0.48 and 0.61, FDR-adjusted P = 5.13 × 10−62 and 5.04 × 10−107) and the new DBS-CRC5 signature (r = 0.43, FDR-adjusted P = 8.21 × 10−47; Supplementary Table 14). This evidence concerns the gene POLE and neoplasm.