Moreover, caspase-1 activation was completely blunted in ASC-deficient or AIM2-deficient, but not in cGAS-deficient, NLRP1-deficient or NLRP3-deficient, BMDMs in response to stimulation with serum from stroke mice or stimulation with DNA (Extended Data Fig. 7c,d). This evidence concerns the gene CASP1 and stroke disorder.