PIK3CA and colorectal carcinoma: These genes included ETV1, detected in the distal colon and previously proposed as a target of enhancer mutations in CRC25; the WNT transcription factor LEF1 (proximal colon); NOTCH2, long proposed to have a role in CRC pathogenesis (distal colorectum)45; the oncogene SRC (distal colorectum); the PI3K–mTOR signalling molecule TFEB (rectum); and the EGFR signalling component DDR2 (proximal colon).