A particularly promising finding in the noncoding human genome comprised recurrent, focal copy number deletions (chromosome 17: 72429007–72450223) in MSI tumours, involving the lincRNA LINC00673 (also known as LINC00511), a transcript that interacts with the CRC driver genes EZH2 and PTPN11 (Supplementary Table 16). The gene discussed is EZH2; the disease is colorectal carcinoma.