During allergen-induced chronic type 2 lung inflammation, alarmin-like cytokines such as interleukin-33 (IL-33), IL-25 and thymic stromal lymphopoietin activate ILC2 proliferation and the vigorous production of type 2 effector cytokines (including IL-4, IL-5, IL-13 and amphiregulin) promoting T helper 2 (TH2) cell differentiation, immunoglobulin E (IgE) production, eosinophilia, mucus hypersecretion and airway contraction, but also aberrant tissue repair that can lead to fibrosis3. This evidence concerns the gene IL33 and Increased total eosinophil count.