Finally, at a substantially higher dose of 60 μg, we measured spillover from on-target tissues (tumor, TDLNs) into off-target tissues (blood, spleen, contralateral LNs) for both αCD45-IL-15 and IgG-IL-15 (Fig. 2b–d and Extended Data Fig. 4a–e). This evidence concerns the gene IL15 and neoplasm.