Intratumoral αCD45-IL-12, followed by peritumorally delivered αCD45-IL-15, displayed comparable early tumor control to the full intratumoral paradigm, but most of these mice (three of five) eventually died, suggesting that optimal long-term tumor control required both doses to be administered i.t. (Extended Data Fig. 6o,p). The gene discussed is IL15; the disease is neoplasm.