However, an integrated analysis by CRISPRi/a suggested an oncogenic role of the miR-23a ~ 27a ~ 24-2 cluster in cell migration may occur through an interaction of miR-23a-BMPR2-Smad-Snail axis and miR-27a-TMEM170B-Twist-β-catenin axis in HCC cells (Supplementary Fig. S11). Here, TWIST1 is linked to hepatocellular carcinoma.