Cell–cell communication analysis indicated that the L-R pairs of EFNA1-EPHA2/4, EFNA5-EPHA2/4, EFNB2-EPHA4, and EFNB2-EPHB1/2 were particularly enriched in SOD2+ iCAFs and other cell types, which are known to facilitate metastasis in malignant tumors (Fig. 6P) [56]. Here, EFNA5 is linked to cancer.