UCCC cancer cells, which engaged in immune-related pathways (e.g., TNFA_SIGNALING_VIA_NFKB, INTERFERON_ALPHA_RESPONSE, IL6_JAK_STAT3_SIGNALING, COMPLEMENT, INFLAMMATORY_RESPONSE), were deemed immune-modulating (Supplementary Fig. 2D). The gene discussed is NFKB1; the disease is cancer.