CTNNB1 and colonic neoplasm: There was also a marked downregulation of the oncogenic Wnt/β-catenin signaling pathway, a gatekeeper of colorectal cancer progression due to APC or CTNNB1 mutations that stabilize β-catenin [29–31, 49–51], with concurrent tumor growth inhibition in vivo compared to colon cancer cells that harbored constitutive BAZ1A expression.