Highlighting critical roles beyond chromatin compaction, the bromodomain (BRD) in BAZ1A binds relatively weakly to acetylated histone peptides [18], making it more available to interact with acetylated non-histone proteins such as Cell Cycle and Apoptosis Regulator (CCAR2) – a Wnt coactivator in colon cancer cells (see below). The gene discussed is BAZ1A; the disease is malignant colon neoplasm.