TNFSF13B and Autoimmunity: We focused on B-cell activating factor (BAFF), a member of the TNF family that regulates B-cell differentiation and maturation and has been linked to autoimmunity [7] and atopic diseases [8, 9], and biomarkers commonly measured in the diagnostic evaluation of rheumatoid arthritis: anti-cyclic citrullinated peptide-3 antibody (anti-CCP3) and two rheumatoid factors (RF-IgM and RF-IgA).