Some studies have shown a higher frequency of alcohol consumption in patients with psoriasis or GT,14 and studies have also shown that smokers have a lower frequency of GT, which may be attributed to the fact that nicotine activates the nicotinic acetylcholine receptors on macrophages, thus leading to a reduction in the synthesis of TNF-α, IL-1 and IL-6,25 these immune cells and cytokines are also important in psoriasis. The gene discussed is TNF; the disease is psoriasis.