EPHA3 and central nervous system cancer: Our analysis, which included freshly resected high-grade gliomas and rapid autopsy pediatric tumors (figure 1A), revealed a significant presence of EphA3, a result consistent with prior findings.22 37 EphA3 demonstrated comparable expression levels when compared with established CAR T cell targets such as CD276 (NCT04385173), EphA2,33 and HER2,34 underscoring its potential for clinical translation.