In addition, 26% of publications (n = 25) reported biochemical elements in the description of the method of AL diagnosis.25,31,34,36,40,51,52,64,68–71,77,78,81,93,95,99,101,104,108,111–113 The most described biochemical markers were leukocytosis and C-reactive protein. This evidence concerns the gene CRP and Increased total leukocyte count.