Using the SARS-CoV-2 Beta variant (B.1.351)–infected mouse model, we found that endogenous Nsun2 mRNA levels also decreased in SARS-CoV-2 Beta variant (B.1.351)–infected group [4 days post infection (dpi)] compared to the uninfected group (Mock) (Fig. 7C). This evidence concerns the gene NSUN2 and infection.