Several recent meta-analyses of randomized clinical trials demonstrated that among individuals with prediabetes and T2D, flaxseed supplementation significantly reduced levels of fasting blood glucose, insulin, HbA1c, and HOMA-IR.31,32 This is consistent with findings from another meta-analysis among healthy individuals showing that lignan intake contributed to better glycemic control.33 The correlation is further supported by our findings in the MLVS, where a higher intake of lignans was associated with decreased levels of HbA1c. This evidence concerns the gene INS and type 2 diabetes mellitus.