ITGA2B and thrombotic disease: Recently, the activation and aggregation of platelets, as indicated by an elevated expression of the integrin αIIbβ3 (GPIIb/IIIa complex, CD41/CD61) and the transmembrane protein P-selectin within the alpha granules, have been strongly linked to thrombotic disorders(Huang et al. 2019; Qiao et al. 2018; Yeini and Satchi-Fainaro 2022).