The %DEspR+CD11b+neutrophils in RA patients are notable given that absolute neutrophil counts (Fig. 3C), and NLR (Fig. 3D) are much lower in RA-flare patients compared to ARDS and sICH patients due to standard-of-care RA-maintenance therapy with pro-neutropenia side effects. Here, ITGAM is linked to acute respiratory distress syndrome.