As DEspR+CD11b+ neutrophils and [NET+Ns] were previously shown to be associated with neutrophilic secondary tissue injury in ARDS and sICH [9, 10], and targetable by anti-DEspR antibody-induced apoptosis [9], observations in this index study support the basis for further studies along the RA pathogenic spectrum as a potential biomarker and/or therapeutic target. This evidence concerns the gene FBXW7-AS1 and acute respiratory distress syndrome.