Flow cytometry analysis of circulating DEspR+CD11b+ neutrophils (35 308 ± 17 647 analyzed per subject) and [NET+Ns] (1428 ± 576 analyzed per subject) detected patient-specific levels of %DEspR+CD11b+neutrophils among all neutrophils gated by forward and side scatter properties in RA-flare patients (Fig. 3A), similar to the range of % DEspR+CD11b+neutrophils observed in patients with ARDS and sICH following identical protocols (Fig. 3B). Here, ITGAM is linked to rheumatoid arthritis.