Briefly, DEspR+CD11b+ activated neutrophils exhibit: (a) increased survival compared to DEspR[−] neutrophils [8]; (b) NET-formation while still in the circulation in sterile inflammation [9], and (c) associated with mortality and clinical measures of severity in acute neutrophil-mediated secondary tissue injury such as acute respiratory distress syndrome (ARDS) [9] and spontaneous primary intracerebral hemorrhage (sICH) [10]. This evidence concerns the gene ITGAM and acute respiratory distress syndrome.