Conflicting reports of whether TNFα-induced RELA translocation is cell cycle regulated may be due to cancer cell type-specific deregulation of cell cycle proteins (Cordon-Cardo, 1995; Otto and Sicinski, 2017) or RELA may not physically interact with E2F1 in PDAC cells in general or specifically in unsynchronised cells. This evidence concerns the gene RELA and cancer.