ADM and neoplasm: CDC42 is involved in the formation of premigratory filopodia in PDAC cells and promotes invasiveness (Razidlo et al., 2018), while RAC1 expression is required for the development of PDAC tumours, in addition to the formation of the ADM and PanIN precursors in KRASG12D mouse models (Heid et al., 2011), indicating that RAC1 may play a role in actin remodelling during PDAC initiation.