Irisin infusion rises asprosin levels in male rats (p1⁄40.02) but not in female rats. Irisin stopped the high glucose, low-density lipoprotein, triglyceride, and leptin levels caused by obesity in all groups, but it did not change the levels of asprosin in either obese male or obese female rats. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.