IL1B and cancer: At the current stage of research, pro-inflammatory cytokine IL1β (Däbritz and Menheniott, 2014) is a key determinant of the risk of human inflammation-related cancers, capable of upregulating inducible nitric oxide levels, thereby abnormally regulating and increasing the activity of nitric oxide-dependent DNMT1 (Wong, 2021; Zhu et al., 2022) (DNA Methyltransferase 1), leading to abnormal silencing or expression of certain genes, especially as over-methylation in gene promoter regions can silence tumor suppressor genes, leading to tumorigenesis.