Moreover, high levels of C1QB expressions were associated with favorable prognosis in basal-like breast cancer (Mangogna et al., 2019a), HER2-positive breast cancer (Mangogna et al., 2019a), skin cutaneous melanoma patients (Liang et al., 2022), and osteosarcoma (Chen et al., 2021). This evidence concerns the gene C1QB and osteosarcoma.