In ovarian cancer, Kaur et al. have reported that exogenous treatment with C1q and the recombinant globular head modules (gC1q) can induce apoptosis in SKOV3 cell line via TNF-α induced apoptosis pathway involving upregulation of Bax and Fas (Kaur et al., 2016). The gene discussed is TNF; the disease is ovarian carcinoma.