THRB and obesity due to melanocortin 4 receptor deficiency: Wang et al. (2014) Lv et al. focused on the mechanisms underlying the impact of DEHP on the pathogenesis of obesity and hypothyroidism as well as the relationship between the two conditions, supported by the downregulation of thyroid hormone receptor beta (TR-beta) and Retinoid X receptors (RXR) genes in DEHP-treated C3H/He mice.