TAAR1 and schizophrenia: Ulotaront (33, SEP-363856) [38] is a phase-3 clinical lead for the treatment of schizophrenia, displaying TAAR1 (trace-amine-associated receptor 1) [39] and 5-HT1A agonism as mode of action, lacking dopamine D2 and 5-HT2A antagonism.