For instance, Xu et al. [101] found brown adipose tissue (BAT) degeneration and exacerbated dysfunction in response to SIRT1 deficiency in mice, while studies by White et al. [132] reported no beneficial effects of SIRT1 overexpression on HFD-induced glucose intolerance, weight gain, or insulin resistance. This evidence concerns the gene SIRT1 and Glucose intolerance.